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Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 333-346 doi: 10.1007/s11684-020-0776-7

Abstract: Upon viral invasion, the innate immune system responds rapidly and plays a key role in activating theadaptive immune system.In the innate immune system, the interactions between pathogen-associated molecular patterns and hostMacrophages, dendritic cells, and natural killer cells are the principal innate immune components thatThis knowledge provides an enhanced understanding of the innate immune response to RNA viral infections

Keywords： innate immune     viral infection     intercellular signaling     metabolic changes     epigenetic changes    

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Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 260-267 doi: 10.15302/J-FASE-2016116

Abstract: The innate immune response is the first line of defense against viral invasion and pro-inflammatory chemokinesand cytokines have a critical function in the innate immune responses against virus infections.leukocytes into the CNS, enhancement of blood brain barrier permeability and activation of various immuneIn addition, recombinant RABV expressing cytokines and chemokines can induce elevated innate and adaptiveimmune responses which result in clearing an established wild-type RABV infection in the CNS.

Keywords： antiviral     blood brain barrier     chemokines and cytokines     innate immunity     rabies virus    

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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibitsthe activation of immune cells through the interaction with its ligand CD24 on tumor cells.

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: Carboplatin in TNBC (DETECT) trial (NCT03295552), decitabine with carboplatin produced an objective responseIn the DETECT trial, decitabine induced strong immune responses featuring the striking upregulation ofthe innate immune player IRF7 in the p53-mutated TNBC cell line (upregulation by 16-fold) and

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

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Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 816-819 doi: 10.1007/s11684-020-0823-4

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Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance Review

Xiaojie Gan, Jian Gu, Zheng Ju, Ling Lu

Engineering 2022, Volume 10, Issue 3,   Pages 44-56 doi: 10.1016/j.eng.2021.03.029

Abstract:

Organ transplant rejection (OTR) is a complex immune reaction involvingHowever, immunosuppressive agents negatively impact the immune system of the patients, causing them toTherefore, a thorough understanding of the mechanisms involved in immune tolerance and immune rejectionThis article reviews the role of immune cells in OTR and organ transplant tolerance (OTT), including

Keywords： Immune cells     Innate immune cells     Adaptive immune cells     Organ transplant     Immune tolerance    

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Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: Due to low response rates to systemic therapies, liver-directed therapies (LDT) are commonly used forThe impact of LDT on the response to systemic treatment is unknown.A total of 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were includedData were analyzed for response to treatment, progression-free survival (PFS), and overall survival (The objective response rate to any ICB (16.7% vs. 3.8%, P =

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 1-5 doi: 10.1007/s11684-014-0309-3

Abstract: instance, fever-range temperature (39β°C to 40β°C) can modulate the activities of immuneCytotoxic temperature (>43β°C) can create an antigen source to induce an anti-tumor immuneresponse.

Keywords： hyperthermia     HPV     immune response     virus     tumor    

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Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric

Jianpeng Liu, Xinhua Chen, Shusen Zheng

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 170-177 doi: 10.1007/s11684-020-0747-z

Abstract: nsPEF can induce the immunogenic cell death of hepatocellular carcinoma (HCC) and stimulate the host’s immuneresponse to kill residual tumor cells and decrease distant metastatic tumors. nsPEF-induced immunityis of great clinical importance because the nonthermal ablation may enhance the immune memory, whichwere illustrated. nsPEF stimulates the host immune system to boost stimulation and prevail suppressionnsPEF increases the dendritic cell loading and inhibits the regulatory responses, thereby improving immune

Keywords： nanosecond pulsed electric fields (nsPEF)     hepatocellular carcinoma (HCC)     immune response     recurrence     metastasis    

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Integrated analysis of gut microbiome and host immune responses in COVID-19

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 263-275 doi: 10.1007/s11684-022-0921-6

Abstract: Emerging evidence indicates that the gut microbiome contributes to the host immune response to infectiousHere, to explore the role of the gut microbiome in the host immune responses in COVID-19, we conductedshotgun metagenomic sequencing and immune profiling of 14 severe/critical and 24 mild/moderate COVIDTogether, our study highlighted a potential regulatory role of severity related gut microbes in the immuneresponse of host.

Keywords： COVID-19     SARS-COV-2     gut microbiome     immune response    

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Universal influenza virus vaccines: what can we learn from the human immune response following exposure

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 471-479 doi: 10.1007/s11684-017-0602-z

Abstract: Here we review what is known about the human humoral immune response to vaccination and infection with

Keywords： universal influenza virus vaccine     hemagglutinin stalk     H7N9    

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Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 95-99 doi: 10.1007/s11684-008-0017-y

Abstract: had a high specificity against mouse-anti-Sj14-3-3 monoclonal antibody and rSj14-3-3 had a promising immune

Keywords： development     challenging     rSj14-3-3     resistance     cultural supernatant    

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Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 390-395 doi: 10.1007/s11684-009-0087-5

Abstract: It was employed to evaluate immune response of the mice inoculated doubly with the DNA vaccine.In conclusion, the EBV DNA vaccine can induce a strong humoral immune response in mice.

Keywords： Epstein-Barr virus     latent membrane protein 2     nasopharyngeal carcinoma     humoral immunity    

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Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 726-745 doi: 10.1007/s11684-020-0746-0

Abstract: Mobilization of endogenous immune cells is also necessary for CAR T cells to obtain their optimal therapeuticeffect given the importance of the innate immune responses in the elimination of malignant tumors.this review, we focus on the recent advances in the engineering of CAR T cell therapies to restore the immuneresponse in solid malignancies, especially with CAR T cells acting as cellular carriers to deliver immunomodulatorsto tumors to mobilize the endogenous immune response.

Keywords： CAR T cells     immunoregulatory molecules     endogenous immune response     solid malignancies    

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Toll-like receptors in innate immunity and infectious diseases

Min-Hao WU, Ping ZHANG, Xi HUANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 385-393 doi: 10.1007/s11684-010-0600-x

Abstract: production of inflammatory cytokines and type I interferons (IFNs) via myeloid differentiation primary responsegene 88 (MyD88)-dependent or-independent signaling respectively, thereby modulating innate and adaptiveThese studies of TLRs in the innate immune system have implications for the prevention and treatment

Keywords： Toll-like receptors     innate immunity     infectious disease     inflammation    

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Title Author Date Type Operation

Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

Journal Article

Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Journal Article

Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Journal Article

Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance

Xiaojie Gan, Jian Gu, Zheng Ju, Ling Lu

Journal Article

Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Journal Article

Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Journal Article

Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric

Jianpeng Liu, Xinhua Chen, Shusen Zheng

Journal Article

Integrated analysis of gut microbiome and host immune responses in COVID-19

Journal Article

Universal influenza virus vaccines: what can we learn from the human immune response following exposure

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Journal Article

Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Journal Article

Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Journal Article

Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Journal Article

Toll-like receptors in innate immunity and infectious diseases

Min-Hao WU, Ping ZHANG, Xi HUANG,

Journal Article